REVIEW   

Otorhinolaryngology 2022 December;72(4):198-203

DOI: 10.23736/S2724-6302.22.02453-7

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

Single-nucleotide polymorphism and downstream signaling associated with chronic rhinosinusitis, asthma, allergy and acetylsalicylic-acid intolerance: a narrative review

Antonino MANIACI ^{1, 2, 3} ✉, Guglielmo ROSOLIA ¹, Nicolò MUSSO ², Dafne BUONGIORNO ², Maria E. DI STEFANO ¹, Giorgia GIUNTA ¹, Salvatore COCUZZA ¹, Giannicola IANNELLA ^{2, 4}, Jerome R. LECHIEN ^{2, 5}, Christian CALVO-HENRIQUEZ ^{2, 6}, Miguel MAYO ^{2, 7}, Egle GRIGALIUTE ¹, Stefano STRAQUADANIO ², Maria SANTAGATI ², Stefania STEFANI ², Ignazio LA MANTIA ¹

¹ ENT Section, Department of Medical, Surgical and Advanced Technologies G.F. Ingrassia, University of Catania, Catania, Italy; ² Rhinology Study Group of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies (YO-IFOS), Paris, France; ³ Department of Biomedical and Biotechnological Sciences (BIOMETEC), Laboratory of Molecular and Resistant Antibiotic Medical Microbiology (MMAR), University of Catania, Catania, Italy; ⁴ Department of Sense Organs, Sapienza University, Rome, Italy; ⁵ ENT Department, Foch Hospital, University of Paris Saclay, Paris, France; ⁶ Service of Otolaryngology, Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain; ⁷ Otorhinolaryngology - Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain

INTRODUCTION: Different Single nucleotide polymorphisms have been described in the literature as being significantly associated with a greater risk than the general population of developing impaired downstream signaling and comorbidities such as chronic rhinosinusitis, asthma, allergy and summary acetylsalicylic-acid (ASA) intolerance.
EVIDENCE ACQUISITION: We conducted a review on comorbidities related to chronic rhinosinusitis such as asthma, allergies, and ASA intolerance among the English-language literature from the past 20 years regarding chronic rhinosinusitis and the association with asthma, allergies, and ASA intolerance was performed.
EVIDENCE SYNTHESIS: We retrieved 12 papers with 9127 patients, of which 2739 CRS cases vs. 6388 controls. The major comorbidities associated with chronic rhinosinusitis were allergy (N.=4555; 49.9%), asthma in (N.=4594; 50.33%), Samter Triad (N.=448; 4.9%) and eosinophilia in subjects (N.=391; 4.28%).
CONCLUSIONS: Our narrative review investigated the major comorbidities significantly associated with chronic rhinosinusitis. Although there is clinical evidence, given the presence of different inclusion methods and given the variability of the populations examined, further studies with larger cohorts are needed to identify stronger associations with the comorbidities and single nucleotide polymorphisms.

KEY WORDS: Asthma; Nasal polyps; Aspirin