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ORIGINAL ARTICLE   

Otorhinolaryngology 2022 June;72(2):64-70

DOI: 10.23736/S2724-6302.22.02404-5

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effect of presbycusis on P3 auditory evoked potentials

Mostafa M. EL KHOUSHT 1, Abeir O. DABBOUS 1, Zainab T. ABD-ELALEIM 2, Hussein S. HAMDY 3

1 Unit of Audiology, Division of Audiological Medicine, Department of Otolaryngology, Kasr-Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt; 2 Unit of Audiology, Section of Audiological Medicine, Department of Otolaryngology, Kasr-Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt; 3 Unit of Audiology, Department of Otolaryngology, Kasr-Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt



BACKGROUND: Aging and hearing loss both affect the central auditory pathway. Brain plasticity of the central auditory system is defined as its property to change its structural and functional organization resulting from peripheral damage and auditory deprivation. Plasticity is expected to be less efficient with age. The aim was to study the effect of presbycusis on P3 at the edge frequency of sloping sensorineural hearing loss (SNHL).
METHODS: Twenty elderly patients with presbycusis were compared to 20 age-matched normal hearing elderly individuals, 20 normal hearing adults, and 10 SNHL adults. P3 at small frequency changes between the common and rare stimuli above the edge frequency of hearing loss; word discrimination scores (WDS) and speech in noise (SPIN) tests were done.
RESULTS: A significantly smaller P3 amplitude was found in presbycusis patients than SNHL adult patients, and in normal hearing elderly than the normal hearing adults especially in 20% higher change condition, with increased P3 latency at 2% condition only, reflecting effect of aging on P3. A statistically significant larger P3 amplitude response was detected in the presbycusis group compared to the normal hearing elderly group, while the amplitudes were comparable to the normal hearing adults. This could be either due to enhanced cortical representation of frequency at the edge frequency of the high frequency SNHL or to the increased loudness of the rare stimulus frequency than that of the edge frequency, adding loudness difference to the frequency difference between rare and common stimuli. Presbycusis group had statistically significantly lower SPIN test scores compared to the normal hearing elderly group and the normal hearing adult group.
CONCLUSIONS: Aging effect and hearing loss in elderly was reflected electrophysiologically and behaviorally on central auditory processing. However, electrophysiological test can reflect auditory central plasticity, but this needs further studies assuring a constant effective stimulus loudness of both the rare and standard tones for recording P3 response in cases of hearing loss.


KEY WORDS: Hearing loss; Presbycusis; Aging

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