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REVIEW  UPDATE ON TRANSLATIONAL RESEARCH AND DIAGNOSTIC-THERAPEUTIC PATHWAYS IN AUDIOLOGY 

Otorhinolaryngology 2021 September;71(3):134-41

DOI: 10.23736/S2724-6302.21.02377-X

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Auditory dysfunction in central nervous system diseases

Stefano DI GIROLAMO , Anisa KAFEXHIU, Mariapia GUERRIERI

Department of Otorhinolaryngology, Tor Vergata University, Rome, Italy



INTRODUCTION: The aim of this review was to illustrate the current literature concerning the emerging evidence of early auditory disfunction affecting patients suffering from different kinds of neurological diseases (Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsies, migraine etc.). The auditory system is deeply integrated with central neural networks, which regulate its function through the efferent auditory pathways, specifically the medial olivocochlear bundle (MOC) that synapses directly to the base of the outer hair cells in the cochlea inhibiting their mobility in order to reduce noise-induced acoustic trauma and to allow detection of acoustic signals in noise. There is evidence of an early impairment of the function of the MOC in case of central neurological diseases, and this can be detected with a simple recording of acoustic otoemissions (OAEs), which are produced by the micromotility of the outer hair cells, which are themselves under control of the efferent auditory system.
EVIDENCE ACQUISITION: A thorough review of literature was performed, analyzing the role of acoustic examination in patients suffering from neurological conditions.
EVIDENCE SYNTHESIS: There is evidence of impairment of both afferent and efferent acoustic pathways in case of neurological diseases.
CONCLUSIONS: Audiological examination may therefore represent a valid complementary tool to be used, together with other neurological investigations, to diagnose, prevent and follow-up qualitatively and quantitatively the effectiveness of treatment of different kinds of neurological diseases.


KEY WORDS: Otolaryngology; Review; Cochlea; Auditory diseases, central

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