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ORIGINAL ARTICLE   Free accessfree

Italian Journal of Dermatology and Venereology 2022 August;157(4):325-9

DOI: 10.23736/S2784-8671.22.07222-X


lingua: Inglese

Serum clusterin levels are not associated with chronic spontaneous urticaria regardless of serum lipids

Eren VURGUN 1 , Bachar MEMET 2, 3, Piril ETIKAN 2, 4, Gulcan GUNTAS 1, 5, Emek KOCATURK 2, 3

1 Department of Medical Biochemistry, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey; 2 Department of Dermatology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey; 3 Department of Dermatology, Koc University School of Medicine, Istanbul, Turkey; 4 Department of Dermatology, Kyrenia Dr. Akcicek Government Hospital, Kyrenia, Cyprus; 5 Department of Medical Biochemistry, Atilim University School of Medicine, Ankara, Turkey

BACKGROUND: Clusterin is related to immunity and inflammation via regulation of complement activation and bidirectional regulation, and by major proinflammatory cytokines. Clusterin levels have been the subject of a few research both in patients with hyperlipidemia and those with chronic spontaneous urticaria (CSU) separately. The aims of this study were to evaluate the levels of clusterin levels and serum lipids and the relationships between them in patients with CSU.
METHODS: Fifty patients with CSU and 30 healthy controls were enrolled into the study. The activity of urticaria of the patients was determined by urticaria activity score (UAS7). Serum clusterin, total cholesterol, HDL, LDL and triglyceride levels of the participants were measured and compared. The relationships between UAS, lipids and clusterin were examined.
RESULTS: There was no difference in clusterin levels between CSU patients and controls. Clusterin level was not related to activity of urticaria. Clusterin levels were not correlated with any of lipid parameters neither in CSU patients nor in controls.
CONCLUSIONS: Findings of this study show that clusterin levels do not change due to CSU. Serum clusterin levels cannot be used as a diagnostic or a disease activity marker in CSU patients, regardless of the lipid profile.

KEY WORDS: Clusterin; Chronic urticaria; Lipids; Hyperlipidemias

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