ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2020 October;155(5):646-51

DOI: 10.23736/S0392-0488.18.05981-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Circulating levels of Apelin-36 in patients with mild to moderate psoriasis

Alessandra CAPO ¹ ✉, Marta DI NICOLA ², Erica COSTANTINI ³, Marcella REALE ³, Paolo AMERIO ¹

¹ Department of Medicine and Aging Sciences, Clinic of Dermatology, G. d’Annunzio University, Chieti, Chieti-Pescara, Italy; ² Biostatistic Laboratory, Department of Experimental and Clinical Sciences, G. d’Annunzio University, Chieti, Chieti-Pescara, Italy; ³ Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University, Chieti, Chieti-Pescara, Italy

BACKGROUND: Affecting vascular function, immune regulation, adipocyte and glucose metabolism, adipokines are essential partecipants in the pathogenesis of psoriatic comorbidities such as metabolic syndrome and insulin resistance. Aim of this study was to measure plasma levels of circulating Apelin-36, a newly discovered peptide hormone acting on glucose metabolism and other adipokines in patients with mild to moderate psoriasis and in a control group.
METHODS: Serum levels of Apelin-36, RBP4, Visfatin, HMW Adiponectin, CRP, fasting glucose and insulin were measured in 19 consecutive patients with mild to moderate psoriasis and 17 healthy subjects.
RESULTS: Homeostasis Model Assessment of Insulin Resistance (HOMA IR) Index was significantly increased in patients with psoriasis respect to a control group and positively correlated with BMI (P=0.009). Apelin-36 showed lower levels in the psoriatic population (P=0.016), while the remaining measured adipokines did not show any significant difference between the two groups.
CONCLUSIONS: In conclusion we confirmed the propensity of psoriatic population to a prediabetic condition even in mild-moderate disease; psoriasis related Apelin-36 lower levels are suggestive of a low-grade inflammatory state. Further studies are needed, to better understand the Apelin related behaviors in different inflammatory settings.

KEY WORDS: Apelin; Psoriasis; Adipokines; Insulin resistance