REVIEW   

Giornale Italiano di Dermatologia e Venereologia 2019 August;154(4):466-79

DOI: 10.23736/S0392-0488.17.05670-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Primary cutaneous B-cell lymphoma: narrative review of the literature

Vieri GRANDI ¹ ✉, Silvia ALBERTI VIOLETTI ², Roberta LA SELVA ³, Stefano CICCHELLI ³, Chiara DELFINO ¹, Paolo FAVA ³, Maria T. FIERRO ³, Alessandro PILERI ^{1, 4}, Nicola PIMPINELLI ¹, Pietro QUAGLINO ³, Emilio BERTI ²

¹ Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy; ² Unit of Dermatology, IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy; ³ Clinic of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; ⁴ Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy

Primary cutaneous B-cell lymphomas comprehend a group of lymphoproliferative disorders characterized by being monoclonal proliferations of B-cell primarily involving the skin. Despite being recognized as autonomous and distinct clinico-pathologic entities since the late 80s, their classification is still an ongoing matter of debate. At the moment, WHO classification recognizes three disorders: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large b-cell lymphoma (leg type). Primary cutaneous diffuse large b-cell lymphoma (other) has been used to define rare cases which show histologically an infiltrate with diffuse pattern composed by large b-cell, but not fitting with criteria for follicle center lymphoma nor for primary cutaneous diffuse large b-cell lymphoma (leg type). Aim of this review was to briefly describe all recognized and provisional entities included in the primary cutaneous b-cell lymphomas and to discuss recent acquisitions that may influence their future classifications.

KEY WORDS: Lymphoma B-cell; Lymphoma, large B-cell, diffuse; Lymphoma, non Hodgkin