ORIGINAL ARTICLES   

Giornale Italiano di Dermatologia e Venereologia 2016 October;151(5):473-9

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo

Lamia H. ELGARHY ¹, Amani ABDULLATIF ¹, Rehab ABDELAZIM ², Karima I. EL-DESOUKY ³ ✉

¹ Department of Dermatology and Venereology, Tanta University, Tanta, Egypt; ² Mehalla Hospital, Tanta, Egypt; ³ Department of Pathology, Tanta University, Tanta, Egypt

BACKGROUND: The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis.
METHODS: Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression.
RESULTS: Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found.
CONCLUSIONS: Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.