Home > Journals > Italian Journal of Vascular and Endovascular Surgery > Past Issues > Italian Journal of Vascular and Endovascular Surgery 2021 September;28(3) > Italian Journal of Vascular and Endovascular Surgery 2021 September;28(3):81-90

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

REVIEW   Freefree

Italian Journal of Vascular and Endovascular Surgery 2021 September;28(3):81-90

DOI: 10.23736/S1824-4777.21.01509-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Arterial thrombosis: the obscure threat in COVID-19 pandemic victims

Bistra P. BONEVA, Margaret P. DIMOVA, Nadelin K. NIKOLOV, Boyka I. STOYANOVA, Boris N. ILCHEV

Department of Vascular Surgery, MBAL National Cardiology Hospital, Sofia, Bulgaria



INTRODUCTION: SARS-CoV-2 is a novel Coronavirus responsible for the current global pandemic resulting in an escalating number of cases and fatalities worldwide. There is a growing number of reports regarding patients presenting with acute limb ischemia due to thrombosis of all arterial beds. We conducted a literature review to identify and summarize the available data regarding the incidence of COVID-19 induced acute peripheral arterial thrombosis, potential pathophysiological mechanisms, clinical representation, diagnosis, surgical outcomes and limb salvage results.
EVIDENCE ACQUISITION: References for this review were identified through searches on PubMed, Ovid Medline, and Embase from December 1, 2019 to March 15, 2021 using relevant terms related to COVID-19. Reference lists of the articles were also searched. Thirty-six publications were deemed relevant for the purpose of this literature review.
EVIDENCE SYNTHESIS: An aggressive and timely medical therapy and surgical interventions should be performed to obtain positive treatment outcomes. Nevertheless, the absence of evidence-based protocols remains an obstacle for healthcare providers. Further quality research about SARS-CoV-2 infection with a focus on arterial thrombotic complications are needed to characterize arterial consequences of Coronavirus and to evaluate the necessity of therapeutic anticoagulation in COVID-19 patients with peripheral arterial occlusive disease or thrombophilia.
CONCLUSIONS: Healthcare providers should be aware of the manifestations of COVID-19 and a high index of suspicion should be maintained so that all can benefit from evidence of measures that have been found to be effective. Although previous reports also identified COVID-19 patients with limb ischemia, there is limited data on the clinical course and treatment.


KEY WORDS: COVID-19; SARS-CoV-2; Coronavirus; Thrombophilia

top of page