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Italian Journal of Vascular and Endovascular Surgery 2017 March;24(1):9-18

DOI: 10.23736/S1824-4777.17.01274-8

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Ulinastatin for inhibiting inflammatory response and protecting liver and renal functions in patients undergoing abdominal surgery: a meta-analysis

Shizhe CHEN 1, Wei WANG 1, Wenqi ZHOU 2, Chunshui LIN 1

1 Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China; 2 Breast Center, Nanfang Hospital, Southern Medical University, Guangzhou, China


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INTRODUCTION: The aim of this report was to value the effectiveness of perioperative ulinastatin on suppressing inflammatory cytokines as well as protecting the postoperative liver and renal functions in abdominal surgery.
EVIDENCE ACQUISITION: We selected RCTs comparing perioperative ulinastatin with placebo in abdominal surgery searching through Ovid, PubMed, Cochrane databases, Medline, SinoMed, SpringerLink and the China National Knowledge Infrastructure. The primary endpoints included interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF-α). The biochemical parameters illustrating postoperative liver and kidney function as well as inflammation response were considered as secondary endpoints. Seventeen RCTs (986 patients) met the inclusion criteria. The meta-analysis was performed by using Revman 5.3.
EVIDENCE SYNTHESIS: Seventeen RCTs (986 patients) met the inclusion criteria. Also, ulinastatin can decrease significantly the level of IL-6,IL-8,TNF-α, alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine (SCr), urea nitrogen (BUN), blood α-microglobulin (blood α-mG), urine α-microglobulin (urine α-mG), white blood cell (WBC) and c reactive protein (CRP) with abdominal surgery.
CONCLUSIONS: Ulinastatin can produce the positive effects on postoperative liver and renal functions in abdominal surgery, via the inhibition of incremental inflammatory agents in postoperation.


KEY WORDS: Ulinastatin - Liver function tests - Kidney

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