PERIPHERAL ARTERIAL DISEASES 

Italian Journal of Vascular and Endovascular Surgery 2014 December;21(4):201-4

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Directional atherectomy and adjunctive drug-coated balloon angioplasty

Sixt S. ¹, Zeller T. ²

¹ Angiologikum, Center for Interventional Angiology, Medical Care Prof. Mathey/Prof. Schofer, Hamburg, Germany; ² University Heart Center, Freiburg Bad Krozingen, Bad Krozingen, Germany

The safety and efficiency of directed atherectomy (DA) have consistently been demonstrated in multiple clinical trails. The mechanical excision of the intima, however, seems to induce a reasonable inflammatory response which limit the long term clinical benefit. To control this inflammatory process it has been proposed to apply antiproliferative drugs, via a paclitaxel coated balloon (DCB). The combination of DA and consecutively DCB has the potential to provide optimal vessel preparation and to improve drug uptake during balloon angioplasty.