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Italian Journal of Vascular and Endovascular Surgery 2012 June;19(2):61-8

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: English

Advantages and limitations of drug eluting balloons

Bosiers M. 1, Deloose K. 1, Callaert J. 1, Maene L. 2, Keirse K. 3, Verbist J. 4, Peeters P. 4

1 Department Vascular Surgery, A.Z. Sint-Blasius, Dendermonde, Belgium; 2 Department Vascular Surgery, OLV, Aalst, Belgium; 3 Department Vascular Surgery, R.Z. Heilig-Hart, Tienen, Belgium; 4 Department Cardiovascular and Thoracic Surgery, Imelda Hospital, Bonheiden, Belgium


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Ever since its introduction, one of the major limitations of endovascular therapy is the occurrence of restenosis after treatment. Factors contributing to loss of primary patency after percutaneous transluminal angioplasty (PTA) due to balloon injury are negative arterial remodeling, excessive neointimal proliferation and elastic recoil. In order to increase sustained vessel patency, systemic medication administration and brachytherapy have been proposed, but did not lead to any success. With the introduction of stents, patency rates have been optimized also on longer term. However, neointimal hyperplasia after endovascular stent placement in infra-inguinal arteries remains a major limiting issue. Stents themselves contribute to this excessive intimal formation because of the vascular response to the metallic prosthesis. In order to find a solution to overcome this limitation, the possibilities of drug-eluting technologies are being searched.

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