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The Journal of Sports Medicine and Physical Fitness 2021 Jul 27

DOI: 10.23736/S0022-4707.21.12246-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Downhill running exercise increases circulating level of myokine meteorin-like hormone in humans

Aliakbar ALIZADEH 1, Hamid ALIZADEH 2

1 Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran; 2 Department of exercise physiology, School of sports sciences, University of Mazandaran, Babolsar, Mazandaran, Iran


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BACKGROUND: Meteorin-like hormone (Metrnl) is a myokine with immunoregulatory traits. The aim of this study was to evaluate the response of plasma Metrnl level to a downhill running exercise (DHRE) in humans.
MATERIALS AND METHODS: Twenty active male college students (aged: 22±1.5 years, BMI: 23.50±2.91kg/m2) completed this study. They performed a skeletal muscle damaging exercise protocol e.g., downhill running exercise (DHRE) on treadmill. Blood samples were drawn before and after the exercise protocol to measure plasmatic values of Metrnl, eosinophil count, creatine kinase (CK) and lactate dehydrogenase (LDH).
RESULTS: Plasma Metrnl level showed a significantly-increased level in response to the DHRE (P=0.007). CK (P=0.004), LDH (P=0.001) and the number of plasma eosinophils (P=0.002) also showed significantly-increased values following DHRE. Additionally, we found a significant and positive correlation between changes of plasma Metrnl level with those of the number of eosinophils (p<0.05).
CONCLUSIONS: Downhill running exercise associated with noticeable skeletal muscle damage is accompanied by significantly-increased plasma Metrnl level as well as eosinophils in sedentary humans.


KEY WORDS: Meteorin-like hormone; Immune cells; Downhill running exercise; Skeletal muscle damage markers

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