Home > Journals > The Journal of Sports Medicine and Physical Fitness > Past Issues > Articles online first > The Journal of Sports Medicine and Physical Fitness 2020 Dec 11

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

 

The Journal of Sports Medicine and Physical Fitness 2020 Dec 11

DOI: 10.23736/S0022-4707.20.11946-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Beta-alanine fails to improve on 5,000 m running time despite increasing PAT1 expression in long-distance runners

Gabriel S. FRANCO 1, 2 , Natália Y. NORONHA 1, Bruno A. OLIVEIRA 1, Flávia C. FERREIRA 1, Ana Paula PINTO 3, Camila F. BRANDAO 4, 5, Marcelo PAPOTI 6, Carla B. NONINO 1

1 Nutrigenomics Studies Laboratory, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; 2 Departament of Nutrition, University of Franca, São Paulo, Brazil; 3 Exercise Physiology and Metabolism Laboratory, Ribeirão Preto School of Physical Education and Sport, University of São Paulo, Ribeirão Preto, Brazil; 4 Nutrology Division, Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; 5 State University of Minas Gerais, Divinópolis, Minas Gerais, Brazil; 6 Water Activities Laboratory, Ribeirão Preto School of Physical Education and Sport, University of São Paulo, Ribeirão Preto, Brazil


PDF


BACKGROUND: Beta-alanine has become a dietary supplement widely used by athletes due to its ergogenic effect. However, there is still no consensus on the performance benefit of beta-alanine on exercise lasting longer than ten minutes. The present study aimed to evaluate the effect of beta-alanine supplementation on running performance and the expression of TauT and PAT1.
METHODS: This double-blind, randomized study enrolled 16 long-distance runners (37 ± 8 years) who were randomly allocated to two groups: Placebo (PLA) and Beta-alanine (BA) (4.8 g·day-1) for four weeks. Maximal oxygen consumption, anthropometry, body composition, and food intake were determined. Before and after the intervention, the athletes undertook a 5,000 m running time trial. Venous blood (TauT and PAT1 expressions) and ear lobe capillary blood (lactate) collected before and after exercise. Between tests, we monitored the training variables.
RESULTS: The results were analyzed by T-tests and an ANOVA of repeated measures, with Sidak’s post hoc (p<0.05). PLA exhibited lower body fat than BA (8.7 ± 2.2 vs. 11.5 ± 2.8%, p=0.04). After supplementation, there was an increase in PAT1 expression in BA when compared to PLA (1.17 ± 0.47 vs. 0.77 ± 0.18, p=0.04). No significant differences were shown for the 5,000 m running time in PLA (PRE:1128 ± 72; POST:1123 ± 72s) and BA (PRE:1107 ± 95; POST:1093 ± 86s).
CONCLUSIONS: Although beta-alanine supplementation increased PAT1 expression, there was no statistically significant improvement in 5,000 m running performance. However, individual responses should be considered as the BA showed a higher delta than the PLA.


KEY WORDS: Athletic performance; Dietary supplements; Gene expression

top of page