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A Journal on Applied Physiology, Biomechanics, Preventive Medicine,
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The Journal of Sports Medicine and Physical Fitness 2018 Mar 01

DOI: 10.23736/S0022-4707.18.08258-0


language: English

Type 2 diabetes mellitus risk and exercise: is resistin involved?

Christian COBBOLD

School of Science, Australian Catholic University, Banyo, Australia


Obesity and associated disorders such as type 2 diabetes mellitus (T2DM) pose an increasing risk to the health of both individuals and society. Adipose tissue is an active endocrine organ, secreting many hormones, known as adipokines. Evidence suggests that one suggest adipokine, resistin, may be elevated in the plasma of individuals with T2DM, and early reports indicated that this may contribute to the impaired glucose tolerance and insulin resistance observed in T2DM, hence its name, resistin, however subsequent evidence suggests it may have a proinflammatory role. Performing regular exercise and dietary interventions improve insulin sensitivity and glucose tolerance in the majority of individuals with T2DM, and we hypothesised that plasma resistin levels may drop in individuals following a long term aerobic and/or resistance exercise intervention programme. Articles analysing the effects of exercise on serum resistin levels were therefore analysed. Articles were selected and analysed based on a minimum aerobic and/or resistance training programme of 2 sessions per week for 12 weeks. Plasma resistin levels decreased following either endurance aerobic exercise and/or resistance training plans in individuals with obesity and/or insulin resistance, although this was not related to BMI change. Exercise intervention programmes generally showed potentially beneficial changes in plasma resistin concentrations. It is possible these effects are mediated through exercise-induced decreases in inflammation via anti-inflammatory cytokine release rather than alterations in glucose metabolism and reductions in BMI per se. A possible link between resistin, exercise and T2DM is discussed.

KEY WORDS: Exercise - Type 2 diabetes mellitus - Resistin - Inflammation - Insulin resistance

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Publication History

Article first published online: March 01, 2018
Manuscript accepted: January 25, 2018
Manuscript revised: January 9, 2018
Manuscript received: October 10, 2017

Cite this article as

Cobbold C. Type 2 diabetes mellitus risk and exercise: is resistin involved?. J Sports Med Phys Fitness 2018 Mar 01. DOI: 10.23736/S0022-4707.18.08258-0

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