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The Journal of Sports Medicine and Physical Fitness 2021 October;61(10):1416-22

DOI: 10.23736/S0022-4707.20.11693-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Changes in mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training

Fatemeh HEIAT 1, Mohammad HEIAT 2, Manzarbanoo SHOJAEIFARD 3, 4

1 Department of Physical Education and Sport Sciences, Fasa Branch, Islamic Azad University, Fasa, Iran; 2 Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran; 3 Department of Physiology, Fasa University of Medical Sciences, Fasa, Iran; 4 Ionizing and Non-ionizing Radiation Protection Research Center (INRPRC), Shiraz University of Medical Sciences, Shiraz, Iran



BACKGROUND: Oxidative stress and mitochondrial dysfunction can be tracked down in most liver diseases like non-alcoholic fatty liver disease (NAFLD). The most recommended preventative method is lifestyle modification, especially exercise. The aim of this study was the investigation of changes in the indexes of mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training.
METHODS: Thirty healthy male rats were divided into three control (C=10), Continuous swimming training (CT=10) and High intensity interval swimming training groups (HIIT=10). The training groups performed their specific exercises 5 days a week for 8 weeks. 24 h after the last training session in order to prepare the serum, a blood sample was taken from the left ventricle of the rats. In addition, liver tissue was extracted and the SIRT3, PGC-1α, GSH:GSSG, MDA, LDL, HDL, LDL:HDL, TG, TC, AST, ALT and FBS variables were measured by ELISA and analysis of blood biochemistry.
RESULTS: Continuous training (CT) increased the levels of PGC-1α, SIRT3 and significantly reduced LDL, LDL:HDL, TG and FBS (P<0.05) levels. High-intensity interval training (HIIT) caused a significant increase in SIRT3 and a significant decrease in FBS (P<0.05) levels.
CONCLUSIONS: Adaptations resulting from further aerobic exercise can increase mitochondrial biogenesis factors such as PGC-1α and SIRT3 in hepatocytes, improve this process in hepatocytes, and ultimately improve the fatty liver markers. Therefore, CT may be more effective than HIIT in preventing fatty liver disease.


KEY WORDS: Free radicals; High-intensity interval training; Organelle biogenesis; Non-alcoholic fatty liver; Sirtuin 3

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