ORIGINAL ARTICLE  EPIDEMIOLOGY AND CLINICAL MEDICINE 

The Journal of Sports Medicine and Physical Fitness 2020 April;60(4):625-33

DOI: 10.23736/S0022-4707.20.10403-1

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

How to exercise to increase lipolysis and insulin sensitivity: Fasting or following a single high-protein breakfast

Marziyeh SAGHEBJOO ✉, Nasrin KARGAR-AKBARIYEH, Mohsen MOHAMMADNIA-AHMADI, Iman SAFFARI

Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran

BACKGROUND: The purpose of this study was to investigate the lipolysis response and insulin sensitivity to high-intensity interval exercise (HIIE) upon fasting (HIIEFAST) and following the intake of a high-protein breakfast (HIIEHPFED).
METHODS: Overweight men participated in two sessions of HIIE after an overnight fast and post-HPFED with an interval of one week. Metabolic biomarkers were assessed before, immediately after, and 3h postexercise. To evaluate the metabolic effects of HIIE, two-way repeated-measures ANOVA was used.
RESULTS: Glycerol levels increased immediately after HIIEFAST and HIIEHPFED (P=0.0001) and decreased 3h after exercise in both states (P=0.001). There were no significant changes in free fatty acid (FFA) levels immediately after exercise, but a significant increase was observed 3h after exercise compared to the baseline and immediately after exercise in HIIEFAST and HIIEHPFED (P=0.0001). Insulin sensitivity was increased for 3h after HIIEHPFED compared to the baseline and immediately after exercise (P=0.04).
CONCLUSIONS: These findings suggest that fasting during exercise is not necessary for the greater stimulation of lipolysis and an increase in insulin sensitivity and that exercise following a high-protein breakfast can have a similar effect in overweight young men.

KEY WORDS: High-intensity interval training; Overweight; Diet; Fatty acids, nonesterified; Glycerol