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ORIGINAL ARTICLE  EPIDEMIOLOGY AND CLINICAL MEDICINE 

The Journal of Sports Medicine and Physical Fitness 2018 November;58(11):1681-7

DOI: 10.23736/S0022-4707.17.06763-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Evaluation of anabolic steroid induced renal damage with sonography in bodybuilders

Umut H. KANTARCI 1 , Zekine PUNDUK 2, Omer SENARSLAN 3, Alper DIRIK 4

1 Department of Radiology, Esrefpasa Hospital, Izmir, Turkey; 2 Department of Physical Education and Sports, Balikesir University, Balikesir, Turkey; 3 Department of Cardiology, Special Medifema Hospital, Izmir, Turkey; 4 Department of Urology, Special Ege Sehir Hospital, Izmir, Turkey



BACKGROUND: The aim of this study was to investigate the effect of anabolic steroids on kidneys in bodybuilders.
METHODS: Twenty-two bodybuilders were included in the study. Participants were divided into three groups according to the scheme of steroid usage: group 1 (N.=8, intramuscular 500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone for 12 weeks), group 2 (N.=7, intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate for 16 weeks), and group 3 (N.=7, no steroid intake). Blood urea nitrogen (BUN), creatinine (Cr), urine micro-albumin and electrolyte levels were measured. Renal volume, cortical thickness and echogenicity were obtained in ultrasonographic scans.
RESULTS: Renal volume, cortical thickness, echogenicity and protein intake value were significantly higher in group 2 than group 1 and 3. Plasma levels of BUN and Cr in group 2 were significantly higher than other groups (P˂0.001). Urine microalbumin and electrolyte levels were normal in all groups.
CONCLUSIONS: The results of this study indicate that high protein intake, steroid usage, particularly the schemes, including boldenone undecylenate increases cortical echogenicity, thickness of renal parenchyma and renal volume in bodybuilders.


KEY WORDS: Steroids - Renal insufficiency - Acute kidney injury - Proteins

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