![]() |
JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Publication history |
Reprints |
Permissions |
Cite this article as |
Share |


YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
ORIGINAL ARTICLE EXERCISE PHYSIOLOGY AND BIOMECHANICS
The Journal of Sports Medicine and Physical Fitness 2017 January-February;57(1-2):18-25
DOI: 10.23736/S0022-4707.16.05871-0
Copyright © 2015 EDIZIONI MINERVA MEDICA
language: English
Androgen receptor CAG and GGN repeat polymorphisms influence performance in boys and girls
Lorena RODRÍGUEZ-GARCÍA 1, 2, Jesús G. PONCE-GONZÁLEZ 1, 2, Juan J. GONZÁLEZ-HENRÍQUEZ 2, 3, Francisco G. RODRÍGUEZ-GONZÁLEZ 4, 5, Bonifacio N. DÍAZ-CHICO 4, 5, Jose A. CALBET 1, 2, Cecilia DORADO 1, 2, Amelia GUADALUPE-GRAU 1 ✉
1 Department of Physical Education, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; 2 Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; 3 Department of Mathematics, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; 4 Department of Biochemistry and Physiology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; 5 Canary Islands Cancer Research Institute (ICIC), Las Palmas de Gran Canaria, Spain
BACKGROUND: Shorter CAG and GGN androgen receptor (AR) repeat polymorphisms are associated with stronger androgen signaling, and therefore, could influence lean mass and exercise performance during growth.
METHODS: Physical fitness and body composition were measured by standardized procedures and the length of CAG and GGN repeats was determined by PCR and fragment analysis in 152 boys (11.5±2.6 years; Tanner ≤5) and 116 girls (10.1±3.2 years; Tanner ≤5). Individuals were grouped as CAG short (CAGS) if harboring repeat lengths of ≤21 and CAG long (CAGL) if CAG >21. Moreover, subjects were grouped as GGN short (GGNS) if harboring repeat lengths of ≤23 and GGN long (GGNL) if GGN>23.
RESULTS: No significant differences in anthropometrics and body composition were observed between either CAGS and CAGL groups and GGNS and GGNL groups. Boys harboring CAGS completed the 300-meter test faster than their CAGL counterparts. Moreover, girls from the GGNL group showed a significant higher VO2max than those in the GGNS group.
CONCLUSIONS: In summary, carrying a short allele of the androgen receptor CAG repeat polymorphism is associated to higher anaerobic performance in boys, whereas long alleles of androgen receptor GGN polymorphisms are associated to higher aerobic capacity in girls.
KEY WORDS: Muscle strength - Androgen receptors - Genetic polymorphism - Physical fitness - Growth and development