Home > Journals > Journal of Radiological Review > Past Issues > Il Giornale Italiano di Radiologia Medica 2019 Novembre-Dicembre;6(6) > Il Giornale Italiano di Radiologia Medica 2019 Novembre-Dicembre;6(6):563-70

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

PICTORIAL ESSAY   

Il Giornale Italiano di Radiologia Medica 2019 Novembre-Dicembre;6(6):563-70

DOI: 10.23736/S2283-8376.19.00228-6

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English, Italian

Imaging of squamous cell carcinomas of the oropharynx

Giovanni B. VERRONE 1, Antonio L. ANNESE 1, Eleonora BICCI 1, Michele PIETRAGALLA 2, Cosimo NARDI 2, Francesco MUNGAI 1, Luigi BONASERA 1 , Vittorio MIELE 1

1 Department of Emergency Radiology, Careggi University Hospital, Florence, Italy; 2 Mario Serio Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy


PDF


Human papilloma virus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) represents a pathological entity whose incidence is increasing rapidly, despite a gradual reduction in alcohol and tobacco consumption in Western countries. The typical sites of onset are the palatine and lingual tonsils. HPV+ carcinomas have different morphological, clinical, histopathological and prognostic features compared to HPV-negative (HPV-) tumors and are more responsive to combined chemo-radiotherapy treatments. Therefore, in the new version of the TNM staging system, made by the AJCC, the staging categories of HPV+ tumors differ from those of HPV- tumors. HPV+ tumors occur more frequently with an expanding growth pattern, well-defined margins and reduced tendency to invade the underlying muscle planes. Locoregional lymph node localization, which often represents the clinical onset of disease, typically have a cystic appearance with homogeneous content, thin margins and a regular profile, characteristics that can be better assessed in MRI. Furthermore, lymph node metastases may be the only clinically detectable tumor localization (T0 in HPV+ or Tx in HPV-; N+). It is possible to suspect the presence of the virus by evaluating both the primary lesion and the locoregional lymph node metastases, in particular in MRI.


KEY WORDS: Oropharyngeal neoplasms; X-ray computed tomography; Magnetic resonance imaging

top of page