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Il Giornale Italiano di Radiologia Medica 2018 Luglio-Agosto;5(4):529-33

DOI: 10.23736/S2283-8376.18.00103-1

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: Italian

Hodgkin’s lymphoma and nephrotic syndrome: a rare case in a child

Carmela BRILLANTINO 1 , Eugenio ROSSI 1, Luisa CASTELLI 1, Salvatore BUFFARDI 2, Maria Elena ERRICO 3, Mattia CARBONE 4, Rocco MINELLI 5, Raffaele ZECCOLINI 5, Massimo ZECCOLINI 6

1 Unità Semplice Dipartimentale di Radiologia ed Ecografia, Ospedale Pausilipon, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italia: 2 Dipartimento di Oncoematologia, Ospedale Pausilipon, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italia; 3 Struttura Complessa di Anatomia Patologica, Ospedale Pausilipon, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italia; 4 Unità Operativa Complessa di Radiologia, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi di Aragona, Salerno, Italia; 5 Università degli Studi della Campania Luigi Vanvitelli, Napoli, Italia; 6 Unità Operativa Complessa di Radiologia, Ospedale Santobono, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italia


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In Italy, Hodgkin’s lymphoma (HL) constitutes 6% of the tumors and 43% of all lymphomas in the age group between 0 and 14 years and is more frequent in males. Patients with HL, in most cases, present at the time of diagnosis lymphadenopathy, mainly latero-cervical and/or thoracic; conversely, abdominal presentation and/or systemic symptoms such as fever, weight loss and night sweats are infrequent. HL rarely manifests itself with the clinical picture of nephrotic syndrome (NS). In pediatric age, the annual incidence rate of NS is 2-5 cases per 100,000 children and in young patients aged less than 8 years it is more frequent in males; it is usually idiopathic, but there are congenital or secondary forms to glomerulonephritis and systemic diseases. NS is associated with HL only in 1% of cases. Minimal change nephropathy is the most common renal disease found in children with HL. The glomerular lesion causes an increase in the permeability of the wall of the glomerular capillaries and consequently the NS is manifested by proteinuria, hypoalbuminemia, decreased plasma oncotic pressure and edema. In the present article we describe the rare case of a 7-year-old girl, who came to our observation with NS, who was resistant to corticosteroid treatment. After about two months HL was diagnosed in the abdomen.


KEY WORDS: Hodgkin disease - Nephrotic syndrome - Ultrasonography - X-ray computed tomography - Positron-emission tomography computed tomography

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