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Il Giornale Italiano di Radiologia Medica 2018 Maggio-Giugno;5(3):354-60

DOI: 10.23736/S2283-8376.18.00064-5


language: Italian

MR mammography and molecular classification of infiltrating breast cancer in young women

Michele LORENZON 1 , Agostino SERGIO 2, Anna LINDA 1, Adriana NITTI 1, Rossano GIROMETTI 1, Massimo BAZZOCCHI 3, Chiara ZUIANI 1

1 Istituto di Radiologia, Presidio Ospedaliero Santa Maria della Misericordia, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italia; 2 Struttura Complessa di Radiologia di San Vito, Spilimbergo e Maniago, Azienda per l’Assistenza Sanitaria n. 5 del Friuli Occidentale, Pordenone, Italia; 3 Studio Radiologico, Trieste, Italia


BACKGROUND: The aim of this study was to correlate morphological and dynamic features of MR mammography with molecular subtypes of infiltrating breast cancer in young women.
METHODS: 1.5-T MR mammography obtained for local staging in our Institute in women aged 40 or younger with infiltrating breast cancer diagnosed in the period between October 15th, 2010 and December 31st, 2015 were retrospectively assessed by two radiologists in consensus, with respect to presentation modality (mass vs. non-mass) and, for mass lesions, to shape, margins, size, enhancement pattern (homogenous, heterogeneous, rim), signal intensity/time curve and enhancement rate (ACR BIRADS 2013). All MR features were correlated to molecular classification (luminal A, luminal B, HER2+, triple negative). Statistical analysis was performed with Fisher and Kruskal-Wallis tests. P<0.05 were considered statistically significant.
RESULTS: Fifty-three women (mean age: 36 years and 10 months) were identified. Twenty of them were affected by luminal A (38%), 16 by luminal B (30%), 7 by HER2+ (13%), and 10 by triple negative (19%) infiltrating carcinomas. In mass lesions (48/53), the mean size of triple negative (38.7 mm) and HER2+ (41.2 mm) cancers was bigger than in luminal A (22.2 mm) and luminal B (24.6 mm) groups, and the difference was statistically significant (P=0.0057). Enhancement pattern distribution was statistically different (P=0.002), with rim enhancement rate higher in triple negative (56%) and HER2+ (33%) than in luminal A (11%) and luminal B (0%). The other morphological and dynamic MR features were not significantly different among molecular subtypes.
CONCLUSIONS: In our experience, there is a close relationship among molecular subtypes of invasive carcinomas in young women and MR features. MR characteristics suggestive for aggressiveness are more frequently associated with biologically aggressive lesions, and this is coherent with previously published papers.

KEY WORDS: Breast neoplasms - Phenotype - Women - Magnetic resonance imaging

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