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Il Giornale Italiano di Radiologia Medica 2018 Gennaio-Febbraio;5(1):153-6

DOI: 10.23736/S2283-8376.17.00010-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: Italian

A rare case of head and neck amyloidosis

Luigi BONASERA 1, Michele PIETRAGALLA 2 , Alba PIACENTI 2, Gloria ADDEO 2, Giuseppe CARACCHINI 3, Francesco MUNGAI 1, Cosimo NARDI 2, Vittorio MIELE 1

1 Struttura Organizzativa Dipartimentale Radiodiagnostica di Emergenza Urgenza, Dipartimento dei Servizi, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italia; 2 Dipartimento di Scienze Biomediche Sperimentali “Mario Serio”, Istituto di Radiologia dell’Università, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italia; 3 Struttura Organizzativa Dipartimentale Radiodiagnostica Specialistica, Dipartimento dei Servizi, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italia


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Localized amyloidosis of the nasopharynx represents an extremely rare pathology with only a few cases described in literature. It is characterized by a submucosal deposition of amyloid protein material in nasopharyngeal walls which leads to the formation of an exophytic mass that causes airways obstruction causing nonspecific symptoms like dyspnea, nasal bleeding, nasal obstruction and Eustachian tube dysfunction. The roles of diagnostic imaging (CECT and/or contrast MRI) are the evaluation of the real extension of the lesion in deep neck spaces and the exclusion of other sites of disease (PET). We describe a case of a 23-year-old woman which has come to our attention in order to perform a head and neck contrast MRI for the evaluation of a nasopharynx submucosal exophytic mass highlighted during an ENT visit. The patients complained symptoms of about 1 year characterized by multiple episodes of right acute media otitis, ipsilateral transmission deafness and sore throat. Histopathological examination of tissues obtained by biopsy performed during endoscopic evaluation revealed submucosal deposition of amyloid material confirmed the diagnosis of amyloidosis.


KEY WORDS: Amyloidosis - Nasopharynx - Magnetic resonance imaging - Positron-emission tomography computed tomography - Nasal obstruction - Otitis media

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