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Il Giornale Italiano di Radiologia Medica 2018 Gennaio-Febbraio;5(1):66-72

DOI: 10.23736/S2283-8376.18.00026-8

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: Italian

Longitudinal evaluation of emphysema with low dose CT (LDCT): influence of pulmonary volumes

Chiara ROMEI 1 , Barbara CONTI 2, Pietro BEMI 1, Letizia MARCONI 2, Laura CARROZZI 2, Ferruccio AQUILINI 2, Antonio PALLA 2, Fabio FALASCHI 1

1 Radiologia II, Azienda Ospedaliera-Universitaria Pisana, Pisa, Italia; 2 Pneumologia, Azienda Ospedaliera-Universitaria Pisana, Pisa, Italia


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BACKGROUND: The purpose of our study was to assess the influence of lung volume changes on longitudinal evaluation of emphysema with low-dose computed tomography (LDCT).
METHODS: Were evaluated 284 subjects in the active arm of the study (Pisa Center) with LDCT performed at the first (T1) and third (T3) control, after two years. The parameters analyzed were: total lung volume (mL) and 15th percentile density (PD15, g/L). The subjects were divided in four categories on the basis of smoking habit (persistent smokers, persistent former smokers, quitters and restarter). Were compared the results of longitudinal evaluation of the lung density measured without and with volume correction, this latter performed with 3 different methods based on sponge-model and standardized by: 1) estimated total lung capacity (TLC) based on gender and height; 2) lung mass measured at T1 (density × volume); 3) both.
RESULTS: The difference in the 15th percentile measured between T1 and T3 evaluated on the entire population depends in a statistically significant way by the volume variations (P<0.001) while became independent if correct for TLC (P=0.99). Differences in 15th percentile measured between T1 and T3 in 4 categories and in the entire population not change trend (increase or decrease) according to the four methods of evaluation and the small quantitative differences found are not statistically significant.
CONCLUSIONS: In our experience, the longitudinal evaluation of short-term emphysema is not changed in a statistically significant way on the basis of volumetric changes occurred.


KEY WORDS: Pulmonary emphysema - X-ray computed tomography - Total lung capacity

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