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Panminerva Medica 2021 Apr 20

DOI: 10.23736/S0031-0808.21.04396-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

The pressioni arteriose monitorate e loro associazioni (PAMELA) research project: a 25-year long journey

Guido GRASSI 1 , Fosca QUARTI-TREVANO 1, raffaella DELL'ORO 1, Cesare CUSPIDI 1, Giuseppe MANCIA 2, 3

1 Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy; 2 Policlinico di Monza, Monza, Italy; 3 University Milano-Bicocca, Milan, Italy


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INTRODUCTION: Among the observational studies performed in the area of blood pressure measurements in the population the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) investigation represents an unique research for a number of reasons.
EVIDENCE ACQUISITION AND SYNTHESIS: The PAMELA study combines clinic, home and 24-hour blood pressure measurements in all partiicipants, which were representative of the general population. Examination included metabolic variables, allowing us to determine the interrelationships between bood pressure and metabolic profile. The protocol also included evaluation of organ damage, such as left ventricular hypertrophy, left ventricular diastolic dysfunction, left atrial dimensions and aortic root diameters. Finally, PAMELA represents one of the few studies with a prolonged follow-up, the last survey being completed three years ago and data collected are actually under analysis. This will allow to update the information related to cardiovascular morbidity and mortality in the study cohort.
CONCLUSIONS: The present paper will provide an overview of the various scientific contributions of the PAMELA study to the epidemiology, pathophysiology and clinical aspects of hypertension and hypertension related cardiovascular risk.


KEY WORDS: Hypertension; Organ damage; Epidemiology; Morbidity and mortality; Cardiovascular

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