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Panminerva Medica 2019 Oct 24

DOI: 10.23736/S0031-0808.19.03655-3


language: English

Newer therapeutic approaches towards the management of diabetes mellitus: an update

Heng L. LIN 1, Fathin N. MOHAMED SHUKRI 1, Eric S. YIH 1, Grace H. SHA 1, Grace S. JING 1, Gan W. JIN 1, Chow W. HOONG 1, Choong Q. YING 1, Bibhu P. PANDA 2, Mayuren CANDASAMY 3, Subrat K. BHATTAMISRA 3

1 School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia; 2 Department of Pharmaceutical Technology, School of Pharmacy, Taylor's University, Lakeside Campus, No 1, Jalan Taylor's, Subang Jaya, Selangor, Malaysia; 3 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia


Diabetes mellitus is a chronic metabolic condition characterised by an elevation of blood glucose levels, resulting from defects in insulin secretion, insulin action, or both. The prevalence of the disease has been rapidly rising all over the globe at an alarming rate. Despite advances in the management of diabetes mellitus, it remains a growing epidemic that has become a significant public health burden due to its high healthcare costs and its complications. There is no cure has yet been found for the disease, however, treatment modalities include insulin and antidiabetic agents along with lifestyle modifications are still the mainstay of therapy for diabetes mellitus. The treatment spectrum for the management of diabetes mellitus has rapidly developed in recent years, with new class of therapeutics and expanded indications. This article focused on the emerging therapeutic approaches other than the conventional pharmacological therapies, which include stem cell therapy, gene therapy, siRNA, nanotechnology and theranostics.

KEY WORDS: Diabetes mellitus; Stem cell therapy; Gene therapy; SiRNA; Nanotechnology; Theranostics

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