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Panminerva Medica 2022 June;64(2):259-64

DOI: 10.23736/S0031-0808.22.04602-X

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

The classification of neuroendocrine neoplasms of the lung and digestive system according to WHO, 5th edition: similarities, differences, challenges, and unmet needs

Francesca SANGUEDOLCE 1 , Magda ZANELLI 2, Andrea PALICELLI 2, Alberto CAVAZZA 2, Loredana DE MARCO 2, Maurizio ZIZZO 3, Stefano ASCANI 4, Matteo LANDRISCINA 5, 6, Guido GIORDANO 5, Francesco SOLLITTO 7, Domenico LOIZZI 7

1 Unit of Pathology, Riuniti Polyclinic, University of Foggia, Foggia, Italy; 2 Unit of Pathology, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy; 3 Unit of Surgical Oncology, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy; 4 Unit of Pathology, Santa Maria di Terni Hospital, University of Perugia, Terni, Italy; 5 Unit of Medical Oncology and Biomolecular Therapy, Department of Medical and Surgical Sciences, Riuniti Polyclinic, University of Foggia, Foggia, Italy; 6 Laboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, Potenza, Italy; 7 Institute of Thoracic Surgery, University of Foggia, Foggia, Italy



Neuroendocrine neoplasms (NENs) are a group of disease entities sharing common morphological, ultrastructural and immunophenotypical features, yet with distinct biological behavior and clinical outcome, ranging from benign to frankly malignant. Accordingly, a spectrum of therapeutic options for each single entity is available, including somatostatin analogues (SSA), mTOR-inhibitors, peptide receptor radionuclide therapy (PRRT), non-platinum and platinum chemotherapy. In the last few decades, several attempts have been made to better stratify these lesions refining the pathological classifications, so as to obtain an optimal correspondence between the scientific terminology and, the predictive and prognostic features of each disease subtype, and achieve a global Classification encompassing NENs arising at different anatomical sites. The aim of this review was to analyze, compare and discuss the main features and issues of the latest WHO Classifications of NENs of the lung and the digestive system, in order to point out the strengths and limitations of our current understanding of these complex diseases.


KEY WORDS: Neurosecretory systems; Neoplasms; Lung; Digestive systems

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