Panminerva Medica 2014 June;56(2 Suppl 3):1-7

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Delphinol® standardized maqui berry extract reduces postprandial blood glucose increase in individuals with impaired glucose regulation by novel mechanism of sodium glucose cotransporter inhibition

Hidalgo J. ¹, Flores C. ², Hidalgo M. A. ¹, Perez M. ³, Yañez A. ³, Quiñones L. ⁴, Caceres D. D. ⁵, Burgos R. A. ¹ ✉

¹ Instituto de Farmacología y Morfofisiología, Universidad Austral de Chile, Valdivia, Chile; ² Centro de Estudios Científicos (CECS), Valdivia, Chile; ³ Instituto de Bioquímica y Microbiología, Universidad Austral de Chile, Valdivia, Chile; ⁴ CQF, Centro de Investigaciones Farmacológicas y Toxicológicas ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile; ⁵ División de Epidemiología Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago de Chile

AIM: The impetus of our study was to investigate the effects of a nutritional supplement Delphinol®, an extract of maqui berries (Aristotelia chilensis) standardised to ≥25% delphinidins and ≥35% total anthocyanins, on postprandial blood glucose and insulin levels and identify the physiologic mechanism involved.
METHODS: Postprandial blood glucose and insulin were investigated in double-blind, placebo-controlled, cross-over fashion in ten volunteers with moderate glucose intolerance. Longer term effects on blood sugar levels were investigated in streptozotocin-diabetic rats over a four months period. Effects of maqui berry delphinidins on sodium-glucose symport were examined in rodent jejenum of the small intestine.
RESULTS: Delphinol® intake prior to rice consumption statistical significantly lowered post prandial blood glucose and insulin as compared to placebo. We identified an inhibition of Na+-dependant glucose transport by delphinidin, the principal polyphenol to which Delphinol® is standardised. In a diabetic rat model the daily oral application of Delphinol® over a period of four months significantly lowered fasting blood glucose levels and reached values indistinguishable from healthy non-diabetic rats.
CONCLUSION: Our results suggest a potential use of Delphinol® for naturally controlling post-prandial blood glucose owed to inhibition of sodium glucose co-transporter in small intestine.