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Panminerva Medica 2012 December;54(1 Suppl 4):11-6


language: English

Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy

Steigerwalt R. 1, Nebbioso M. 1, Appendino G. 2, Belcaro G. 3, Ciammaichella G. 3, Cornelli U. 3, Luzzi R. 3, Togni S. 4, Dugall M. 3, Cesarone M. R. 3, Ippolito E. 3, Errichi B. M. 3, Ledda A. 3, Hosoi M. 3, Corsi M. 3

1 Dipartimento di Scienze Oftalmiche, Uniroma1, Rome, Italy; 2 Dipartimento di Scienze Chimiche Alimentari Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Novara, Italy; 3 Irvine3 Circulation-Vascular Labs, Department of Biomedical Sciences, Chieti-Pescara University, Pescara, Italy; 4 Indena S.p.A., Milano, Italy


BACKGROUND: In the present study, the improvement of diabetic microangiopathy and retinopathy was evaluated in 38 diabetic patients treated with a novel curcumin phospholipids delivery form (Meriva®).
METHODS: Diabetes was diagnosed at least 5 years before inclusion and all patients had signs of retinal oedema and of peripheral microangiopathy. Meriva® was administered at the dosage of 2 tablets/day (each tablet containing 500 mg Meriva® corresponding to 100 mg curcumin) for a period of at least 4 weeks in addition to the standard management plan, while a comparable group of subjects (n = 39) followed the standard management plan alone.
RESULTS: All subjects (treatment and controls) completed the follow-up period, there were no dropouts and Meriva® showed an optimal tolerability. At 4 weeks, microcirculatory and clinical evaluations indicated an improvement of microangiopathy. In terms of peripheral microangiopathy, in the Meriva® group, there was a significant improvement in the venoarteriolar response (p<0.05) and a decrease in the score of peripheral oedema (p<0.05), a sign typically associated with the failure of the venoarteriolar response. At the retinal level, high-resolution, duplex scanning, used to measure retinal flow, showed improvements in the Meriva® treated patients. The evaluation of retinal oedema (Steigerwalt’s scale) showed an improvement associated with improved visual acuity (Snellen scale). There were no clinical or microcirculatory effects in controls.
CONCLUSION: These preliminary observations, indicate the value of curcumin, when administered in a bioavailable form as with Meriva®, in the management of diabetic microangiopathy and retinopathy.

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