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Panminerva Medica 2010 December;52(4):289-95

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

Immunotolerance reaction for allograft-limb in rats induced by gene-modified cell transfusion

Li W. 1, Yue W. J. 1, Yue Q. 2, Yang D. W. 1, Meng Q. G. 1

1 Department of Orthopedic Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China; 2 Medical Research Center, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China


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The therapeutic value of the transforming growth factor beta 1 (TGF-b) in transplantation has been reported; However, cell-mediated gene therapy using TGF-b is not applied to the organ transplantation widely. This study was to evaluate whether TGF-b-modified donor spleen cell specific transfusion in rat heterotopic allo-limb transplantation could induce tolerance tolerogenicity and prolong allograft’s survival time. The Splenic T-cell in Wistar rats responsing to donor spleen cells which received TGF-b-transduced were severely impaired.The Survival time of Sprague-Dawley Allograft-limb in Wistar rats given TGF-b-modified donor spleen cells (5¥106 cells/well, administration of donor TGF-b-transduced donor spleen cells 7 days before transplantation) was extended modestly but significantly.

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