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Panminerva Medica 2000 June;42(2):105-8

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Recurrent spontaneous abortion. Etiologic factors

Patriarca A., Piccioni V., Gigante V., Parise G., Benedetto C.

From the Department of Obstetrics and Gynecology Chair C, University of Turin, Italy


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Background. Spontaneous abor­tion is the ­most com­mon com­pli­ca­tion of preg­nan­cy. It may be ­unique, remain­ing ran­dom and hav­ing no con­se­quenc­es on the repro­duc­tive pro­cess, or it can ­repeat ­itself, start­ing a clin­i­cal pic­ture ­known as recur­rent spon­ta­ne­ous abor­tion or habit­u­al abor­tion. The ­term of RSA syn­drome is ­used to ­define the rep­e­ti­tion of ­three or ­more con­sec­u­tive abor­tions ­before the 24th ­week.
Methods. A pop­u­la­tion of 195 cou­ples ­with recur­rent spon­ta­ne­ous abor­tion ­were ­screened for genet­ic, meta­bol­ic, infec­tive, mor­pho­log­i­cal, endo­crine and auto­im­mune fac­tors. Eighty-­five com­plet­ed the inves­ti­ga­tion, 44 are ­being test­ed and 66 did not com­plete the diag­nos­tic ­course. Causes of recur­rent abor­tion ­were eval­u­at­ed in rela­tion to the peri­od of abor­tion and num­ber of ­embryo los­ses.
Results. Forty-six per­cent of ­patients who com­plet­ed the inves­ti­ga­tion ­turned out to be ­sine cau­sa, ­which is in accor­dance ­with the find­ings in lit­er­a­ture.
Conclusions. Couple ­with RSA ­require accu­rate coun­sel­ling and it is fun­da­men­tal to elim­i­nate any pathol­o­gies ­that can be dis­cov­ered so as to ­improve the like­li­hood of the ­pregnancy’s reach­ing ­term.

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