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Panminerva Medica 1999 September;41(3):227-31

Copyright © 2000 EDIZIONI MINERVA MEDICA

language: English

Haematologic pattern in healthy elderly subjects

Malaguarnera M, Di Fazio I., Vincei E., Bentivegna P., Mangione G., Romano M.

From the Department of Internal Medicine and Geriatrics University of Catania, Catania


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Background. A ­more pro­longed ­life expec­tan­cy is asso­ciat­ed ­with an ­increased mor­bid­ity ­rate ­with ­marked alter­a­tions of phys­io­log­ic and meta­bol­ic func­tions in the ­body. The hae­mat­o­log­ic pat­tern can be mod­i­fied dur­ing age­ing ­because of ­reduced cel­lu­lar rep­li­ca­tion and ­enhanced fibro­sis in the ­bone mar­row. Nevertheless it is not ­clear wheth­er age­ing rep­re­sents the ­cause or the ­result of ­these phe­nom­e­na.
Methods. In ­order to eval­u­ate ­wide vari­a­tion of ­data on the hae­mat­o­log­ic pat­tern in eld­er­ly sub­jects, we stud­ied one hun­dred ­eight ­healthy sub­jects (27 ­males, 81 ­females; rang­ing ­from 50 to 99 ­years), liv­ing in ­their ­home.
Results. We ­observed a reduc­tion in ser­um ­iron and trans­fer­rin and an ­increase in ser­um fer­ri­tin lev­els dur­ing age­ing, ­with a con­se­quen­tial ­iron tis­sue ­stores ­increase.
Conclusions. Our ­data sug­gest­ed ­that senes­cence was asso­ciat­ed ­with an ­increased inci­dence of ane­mia, ­which can­not be con­sid­ered a nor­mal fea­ture of ­aging, the phy­si­cians ­must inves­ti­gate ­each ­cause of ane­mia in eld­er­ly sub­jects. Haematological pat­tern is in the nor­mal ­range in ­healthy eld­er­ly sub­jects, ­even if we ­found sig­nif­i­cant age-­linked ­changes. We con­clude ­that a pro­gres­sive impair­ment of ­bone mar­row func­tions is the ­most impor­tant fac­tor in deter­min­ing sig­nif­i­cant chang­es of hemat­o­poie­sis in ­healthy eld­er­ly sub­jects.

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