REVIEW  MÉNIÈRE'S DISEASE 

Otorinolaringologia 2020 December;70(4):132-6

DOI: 10.23736/S0392-6621.20.02331-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Coming out of the mists of Ménière's disease: serum proteomics and biomarkers discovery for early diagnosis and clinical management

Giuseppe CHIARELLA ¹, Pasquale VIOLA ¹ ✉, Davide PISANI ¹, Donatella MALANGA ^{2, 3}, Claudia CASSANDRO ⁴, Alfonso SCARPA ⁵, Giovanni CUDA ⁶, Ettore CASSANDRO ⁵

¹ Unit of Audiology, Department of Experimental and Clinical Medicine, Regional Center for Cochlear Implants and ENT Diseases, Magna Graecia University, Catanzaro, Italy; ² Laboratory of Molecular Oncology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy; ³ Interdepartmental Center of Services (CIS), Magna Graecia University, Catanzaro, Italy; ⁴ Department of Surgical Sciences, University of Turin, Turin, Italy; ⁵ Department of Medicine and Surgery, University of Salerno, Salerno, Italy; ⁶ Department of Experimental and Clinical Medicine, Research Center for Advanced Biochemistry and Molecular Biology, Magna Graecia University, Catanzaro, Italy

The diagnosis of Ménière disease (MD) is based primarily on clinical symptoms and there is no single feature or subset of features from the history, clinical examination or instrumental tests that are able to establish a certain diagnosis. Identification of diagnostic markers that can discriminate MD more accurately, and also that are reliable, reproducible and easy-to-obtain, could be useful. The pathophysiology of MD is complex and debated. Starting from the pathophysiological hypotheses of the disease, different approaches have been used in order to find useful biomarker candidates for diagnosis. We will present the main results in the literature and our personal experience in the field of molecular diagnostics applied to MD, and specifically of proteomics studies.

KEY WORDS: Ménière disease; Proteomics; Electrophoresis, gel, two-dimensional; Mass spectrometry; Humans