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Otorinolaringologia 2020 June;70(2):43-6

DOI: 10.23736/S0392-6621.20.02262-6

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Antibiotic administration in third molar surgery: a comparison of two protocols

Chiara CORIO, Irene ROMEO, Matteo BRUCOLI, Paolo BOFFANO , Arnaldo BENECH

Division of Maxillofacial Surgery, Maggiore della Carità University Hospital, University of Eastern Piedmont, Novara, Italy



BACKGROUND: Third molar extraction is a common procedure performed in local anesthesia in oral and maxillo-facial surgery. The purpose of this work was to evaluate and compare the different outcomes following two different antibiotic administration protocols.
METHODS: This prospective study included 50 consecutive patients that underwent surgical removal of partially bony impacted third molar between September 2018 to December 2018. The enrolled patients were divided into two groups. Group A was assigned the following drug protocol: 1 g tab amoxicillin with clavulanic acid one hour before and after surgery, 1 g tab twice a day of amoxicillin with clavulanic acid for 6 days; the second group was administered only postoperative antibiotic therapy, 1 g tab twice a day of amoxicillin with clavulanic acid for 6 days. An Oral Health Impact Profile Questionnaire (OHIP-14) was administered following surgery, to assess oral health after the two types of therapy
RESULTS: In 24 patients of the first group and in all the patients of the second group, the facial measurement postoperatively of swelling from day 7 to day 15 has decreased significantly. The same was noticed about the mouth opening at day 7 was already more than 3.5 cm, at day 15 was completely normalized. At day 15, all sign and symptom had regressed. In group 1, the OHIP-14 scores ranged from 5 to 8 with an average value of 7.4; in group 2, they ranged from 4 to 8 with an average value of 7.1.
CONCLUSIONS: The result indicates that the administration of both preoperative and postoperative rather than only postoperative antibiotics showed no significant differences in the development of complications above all infections. There is no justification for routine prescription of both preoperative and postoperative antibiotics.


KEY WORDS: Anti-bacterial agents; Third molar; Operative surgical procedures; Infections

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