Home > Journals > Otorinolaringologia > Past Issues > Otorinolaringologia 2014 June;64(2) > Otorinolaringologia 2014 June;64(2):39-43

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Reprints
Permissions

 

  PROBLEMATIC CHRONIC RHINOSINUSITIS 

Otorinolaringologia 2014 June;64(2):39-43

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

The use of immunologic and histopathologic characteristics to classify chronic rhinosinusitis subtypes

Lam K., Kern R. C.

Department of Otolaryngology, Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA


PDF


Chronic rhinosinusitis (CRS) is a broad clinical syndrome traditionally distinguished primarily by the endoscopic findings of the presence or absence of nasal polyps. Increasing evidence, however, suggests that CRS may be further differentiated by their distinct underlying pathophysiologic mechanisms. Purpose of the study was to review recent insights into the mechanisms of CRS pathogenesis and to assess the potential for a classification of CRS into subtypes. Classification schemes have utilized the immunologic and histopathologic profiles of CRS to characterize the phenotypic and potentially endotypic heterogeneity of this disorder. The CRSsNP phenotype has been linked to a less Th2 and relatively more Th1/Th17 polarization and greater collagen deposition. The CRSwNP phenotype has been associated with a Th2 skewing, elevated IgE levels, tissue edema, and a closer linkage to asthma. The immunohistologic characterization of CRS subtypes reflects the diverse pathophysiologic mechanisms associated with this syndrome. Identification of specific biomarkers associated with these variants may ultimately refine the diagnostic criteria of CRS, permitting the targeting of specific pathways contributing to the symptomatology expressed in individual patients.

top of page