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Otorinolaringologia 2001 December;51(4):169-74

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Lethal midline granuloma. Case report and review of the Literature

Noto R., La Mantia I., Mirabella C., Messina A., Noto P., Serra A.

From the Università degli Studi - Catania Dipartimento di Medicina Interna e Patologie Sistemiche *Istituto di Otorinolaringoiatria


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Destructive diseases of the mid-face show various etiopathogenesis, some of them sometimes showing symptoms of systemic diseases that have complex diagnoses which make a specific therapy necessary. The authors describe a case of Stewart’s granuloma, a rare and aggressive disease which greatly destroys the structures of the central-face with a serious prognosis making medicinal and surgical therapy difficult. The authors examine the etiopathogenesis hypothesis of these diseases, which is still not well-known and describe the diagnosis which allows us to differentiate the other forms already known, for example Wegener’s granulomatosis. Immuno-histochemical, histo-morphological and immunological data are important for the precise diagnosis in these cases.

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