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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2021 Dec 09

DOI: 10.23736/S1824-4785.21.03418-X

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Dosimetry of nuclear medicine therapies: current controversies and impact on treatment optimization

Francesco CICONE 1, 2, 3 , Silvano GNESIN 4, Marta CREMONESI 5

1 PET/RM Unit, Department of Experimental and Clinical Medicine, and Neuroscience Research Centre, Magna Graecia University of Catanzaro, Catanzaro, Italy; 2 Nuclear Medicine Unit, University Hospital Mater Domini, Catanzaro, Italy; 3 University of Lausanne, Lausanne, Switzerland; 4 Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland; 5 Radiation Research Unit, Department of Medical Imaging and Radiation Sciences, Istituto Europeo di Oncologia, IRCCS, Milan, Italy


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Nuclear medicine therapeutic procedures have considerably expanded over the last few years, and their number is expected to grow exponentially in the future. Internal dosimetry has significantly developed as well, but has not yet been uniformly accepted as a valuable tool for prediction of therapeutic efficacy and toxicity. In this paper, we briefly summarise some of the arguments about the implementation of internal dosimetry in clinical practice. In addition, we provide a few examples of radionuclide anticancer therapies for which internal dosimetry demonstrated a significant impact on treatment optimization and patient outcome.


KEY WORDS: Therapeutic radiopharmaceuticals; Internal dosimetry; Treatment optimization; Doseresponse effects; Radiobiology; Dose escalation; Personalized dosimetry

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