Home > Journals > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Past Issues > Articles online first > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2019 Dec 13



To subscribe PROMO
Submit an article
Recommend to your librarian


Publication history
Cite this article as



The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2019 Dec 13

DOI: 10.23736/S1824-4785.19.03178-9


language: English

Uptake pattern of [68Ga]Ga-DOTA-NOC in tissues: implications for inflammatory diseases

Luz K. ANZOLA 1, 2, 3 , Chiara LAURI 2, Carlos E. GRANADOS 4, Bruno LAGANÀ 5, Alberto SIGNORE 2, 3

1 Nuclear Medicine Unit, Clinica Colsanitas, Bogotà, Colombia; 2 Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, “Sapienza” University of Rome, Rome, Italy; 3 Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; 4 Medicina Nuclear, Hospital San Ignacio, Bogotá, Colombia; 5 Rheumatology Unit, Department of Clinical and Molecular Medicine, “Sapienza” University of Rome, Rome, Italy


PURPOSE: [68Ga]Ga-DOTA-NOC binds to somatostatin receptor (SSTR) subtypes 2 and 5, also expressed on lymphocytes and macrophages, but no information is available about uptake in tissues that might be affected by a chronic inflammatory process. Our aim was to obtain normal reference values for :[68Ga]Ga-DOTA-NOC uptake in tissues prone to chronic inflammation.
METHODS: Retrospective study in 81 patients who performed the scan for a suspicion of neuroendocrine tumor (NET). We analysed major joints, salivary glands, thyroid, aortic wall from images acquired after injection of 173,9±1 Mbq of :[68Ga]Ga-DOTA-NOC. We calculated the SUVmax and SUVtarget/SUVgluteus ratio or SUVtarget/SUVaorta ratio. Data are reported as mean±2 or ±3 standard deviations (SD).
RESULTS: SUVmax values appeared more reliable than other ratios. In thyroid we found a mean SUVmax of 1.36±0.45, with no values >3SD; in parotid glands 0.98±0.40, with 2 values>3SD; in submandibular glands 0.99±0.37, with 2 values >3SD; in aortic arch 1.71±0.50, with 1 value >3SD; in thoracic aorta 2.03±0.52, with 1 value >3SD; in abdominal aorta 2.19±0.49, with no value >3SD; in shoulders 0.92±0.31 and in hips 0.87±0.34, with 2 and 4 values >3SD, respectively. These 12 values with SUVmax >3SD, belong to 5 patients, 3 of which had signs of xerostomia and/or arthritis. A statistically significant correlation was observed between SUVmax and age in all examined tissues but in the aorta.
CONCLUSIONS: Tissues in which lymphocytic infiltration may occur show that SUVmax is tissue-dependent. Within tissue variability, an SUVmax greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition.

KEY WORDS: Somatostatin receptors; 68Ga-DOTA-NOC; Inflammation; Autoimmune diseases

top of page