![]() |
JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Publication history |
Reprints |
Permissions |
Cite this article as |
Share |


YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2019 Oct 09
DOI: 10.23736/S1824-4785.19.03184-4
Copyright © 2019 EDIZIONI MINERVA MEDICA
language: English
Fully integrated 18F-FDG PET/MR in large vessel vasculitis
Roberto PADOAN 1 ✉, Filippo CRIMÌ 3, Mara FELICETTI 1, Federica PADOVANO 2, Carmelo LACOGNATA 3, Roberto STRAMARE 3, Emilio QUAIA 3, Diego CECCHIN 2, 4, Franco BUI 2, Pietro ZUCCHETTA 2, Franco SCHIAVON 1
1 Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy; 2 Nuclear Medicine Unit, Department of Medicine DIMED, University of Padua, Padua, Italy; 3 Radiology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy; 4 Padova Neuroscience Center, University of Padua, Padua, Italy
BACKGROUND: To evaluate the usefulness of [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET)/magnetic resonance (MR) in large vessels vasculitis (LVV) patients.
METHODS: We performed an observational retrospective study based on our records. Images were acquired on a PET/MR scanner using 18F-FDG-PET whole body imaging. For each PET scan, a qualitative analysis and a semi-quantitative measure using the maximum of the standardized uptake value (SUVMax) were performed. SUVMax measurements normalized to the liver uptake were categorized using a grading scale. Vessel’s wall thickness (WT) was measured at five fixed points (inferior margin of T5, T9, T12, L3, thickest area-max WT).
RESULTS: 23 LVV patients were included, 56.5% giant cells arteritis, 34.8% Takayasu's arteritis and 8.7% isolated aortitis, all Caucasian, mostly females (82%). We considered 32 PET scans for the LVV group (from min. 1 to max. 3 scans/patient) mainly during follow-up (29/32 scans), and 23 PET scans from a control group of non-metastatic malignancies patients. We found higher SUVMax compared to controls, in all sites, irrespective of clinical disease activity. Mean WT resulted higher in patients than in controls but was not correlated to SUVMax. Mean WT positively correlated with age in both cohorts, inversely correlated to disease duration, while no correlation with SUVMax was observed. The concordance between clinically active disease and PET hypermetabolism was poor (K Cohen 0.33).
CONCLUSIONS: PET/MR is a safe imaging technique capable of detecting inflammation in aortic wall. Low radiological exposure of PET/MR should be considered especially in young women receiving follow-up studies.
KEY WORDS: Vasculitis; Giant cell arteritis; Takayasu’s arteritis; Positron emission tomography; Magnetic resonance