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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2019 Jul 01

DOI: 10.23736/S1824-4785.19.03157-1


language: English

[18F]fluorodeoxyglucose-positron emission tomography and glucose-transporter type 1 (GLUT-1) expression in untreated primary small bowel adenocarcinoma

Thomas HAUSER 1, 2, Tina SCHALLER 3, Xiang LI 4, Thomas WIDMANN 5, Michael C. KREISSL 1, 6

1 Department of Nuclear Medicine, Central Hospital Augsburg, Augsburg, Germany; 2 Radiologie Augsburg-Friedberg, Augsburg, Germany; 3 Department of Pathology, Central Hospital Augsburg, Augsburg, Germany; 4 Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Vienna General Hospital, Medical University of Vienna, Vienna, Austria; 5 Department of Oncology, Asklepiosklinik Triberg, Triberg, Germany; 6 Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany


BACKGROUND: Literature reporting [18F]fluorodexoyglucose positron emission tomography (FDG-PET) of small bowel adenocarcinoma, a rare tumor, is sparse. To assess FDG uptake in small bowel adenocarcinoma, we retrospectively analyzed a large, single-center database and determined the expression of glucose-transporter type 1 (GLUT-1).
METHODS: Screening of PET datasets in the database (N = 28,961 scans) for untreated histologically- confirmed primary small bowel adenocarcinoma revealed evaluable PET datasets for eight patients. Maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively) were calculated via volume-of-interest (VOI) analysis. Additionally, GLUT-1 expression on tumor specimens was prospectively immunohistochemically assessed.
RESULTS: All primary tumors showed high FDG uptake: mean SUVmax was 9.5 ± 2.6 (range: 5.0-13.0) and SUVpeak, 8.1 ± 2.3 (range: 3.9-10.7). Corresponding biopsy specimens (n = 7) demonstrated high GLUT-1 expression.
CONCLUSIONS: Primary small bowel adenocarcinomas have a high GLUT-1 expression. Tumor lesions consistently demonstrated high FDG uptake pre-treatment, suggesting FDG-PET utility in staging and follow-up of these tumors.

KEY WORDS: Small bowel; Adenocarcinoma; FDG-PET; FDG uptake; GLUT-1

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