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REVIEW  PET/CT IMAGING IN AUTOIMMUNE DISORDERS Free accessfree

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2022 September;66(3):234-44

DOI: 10.23736/S1824-4785.22.03461-6

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

[18F]FDG PET/CT in rheumatoid arthritis

Richard N. GRAHAM 1 , Emmanouil PANAGIOTIDIS 2

1 Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK; 2 Department of Nuclear Medicine, Theageneio Cancer Center, Thessaloniki, Greece



[18F]fluorodeoxyglucose (FDG) PET/CT can be used to image the inflammation in rheumatoid arthritis. Specifically, the synovial metabolic activity can be evaluated visually and measured using standard uptake values. Fluorine-18-labeled Sodium fluoride (NaF) PET/CT can be used to determine synovial osteoblastic activity. Response assessment using FDG PET/CT is routine in many cancers and this is now an emerging technique for rheumatoid arthritis. Vasculitis in rheumatoid arthritis (RA) can be also studied with FDG PET/CT and aortic calcification with NaF PET/CT. These techniques could be useful in determining RA disease severity. FDG PET/CT is a useful technique to exclude underlying malignancy when RA does not follow the expected course. A number of novel tracers are being studied with regard to their applicability in rheumatoid arthritis and some of these could even be used in a theranostic manner in the future.


KEY WORDS: Positron-emission tomography; Arthritis, rheumatoid; Fluorodeoxyglucose F18; Inflammation; Theranostic nanomedicine

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