REVIEW  IMAGE-GUIDED SURGERY: FROM CLASSICAL TECHNIQUES TO NOVEL ASPECTS AND APPROACHES 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2021 September;65(3):215-28

DOI: 10.23736/S1824-4785.21.03345-8

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Contemporary update of SPECT tracers and novelties in radioguided surgery: a perspective based on urology

Christoph WÜRNSCHIMMEL ¹ ✉, Mike WENZEL ², Tobias MAURER ^{1, 3}, Renato A. VALDÉS OLMOS ⁴, Sergi VIDAL-SICART ^{5, 6}

¹ Martini-Klinik Prostate Cancer Center, University Hospital of Hamburg-Eppendorf, Hamburg, Germany; ² Department of Urology, University Hospital of Frankfurt, Frankfurt, Germany; ³ Department of Urology, University Hospital of Hamburg-Eppendorf, Hamburg, Germany; ⁴ Section of Nuclear Medicine, Department of Radiology, Interventional Molecular Imaging Laboratory, Leiden University Medical Center, Leiden, the Netherlands; ⁵ Department of Nuclear Medicine, Clinic of Barcelona, Barcelona, Spain; ⁶ Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain

Recent technical advances and implementation of novel radiotracers have further increased the potential of radioguided surgery for a broad variety of malignancies. Indeed, the possibilities for future applications of novel radiotracers in diverse oncological strategies has become more promising than ever. This literature review aims to provide a contemporary update on a selected group of radiotracers and evaluates the usability of radioguided surgery and sentinel node procedures, focusing on most promising advances. For example, the impact of targeted radiotracers on prostate specific membrane antigen (PSMA), CD206 receptor-targeted agents (^99mTc-tilmanocept), and hybrid tracers adding fluorescence to radioguidance (ICG-^99mTc-nanocolloid) as well as targeting hypoxia-induced carbonic anhydrase IX (CAIX) will be covered. Furthermore, future outlooks on the implementation of gold nanoparticles (AuNP’s), but also technical advances in improved radiotracer detection by hybrid gamma devices will be discussed.

KEY WORDS: Surgical procedures, operative; Neoplasms; Oncology service, hospital