Home > Journals > The Quarterly Journal of Nuclear Medicine and Molecular Imaging > Past Issues > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 December;62(4) > The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 December;62(4):369-84

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe PROMO
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

REVIEW  MOLECULAR PET IMAGING IN ADAPTIVE RADIOTHERAPY 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 December;62(4):369-84

DOI: 10.23736/S1824-4785.18.03084-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Image-guided adaptive radiotherapy in patients with locally advanced non-small cell lung cancer: the art of PET

Willem GROOTJANS 1 , Lioe-Fee de GEUS-OEI 1, Johan BUSSINK 2

1 Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; 2 Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands



With a worldwide annual incidence of 1.8 million cases, lung cancer is the most diagnosed form of cancer in men and the third most diagnosed form of cancer in women. Histologically, 80-85% of all lung cancers can be categorized as non-small cell lung cancer (NSCLC). For patients with locally advanced NSCLC, standard of care is fractionated radiotherapy combined with chemotherapy. With the aim of improving clinical outcome of patients with locally advanced NSCLC, combined and intensified treatment approaches are increasingly being used. However, given the heterogeneity of this patient group with respect to tumor biology and subsequent treatment response, a personalized treatment approach is required to optimize therapeutic effect and minimize treatment induced toxicity. Medical imaging, in particular positron emission tomography (PET), before and during the course radiotherapy is increasingly being used to personalize radiotherapy. In this setting, PET imaging can be used to improve delineation of target volumes, employ molecularly-guided dose painting strategies, early response monitoring, prediction and monitoring of treatment-related toxicity. The concept of PET image-guided adaptive radiotherapy (IGART) is an interesting approach to personalize radiotherapy for patients with locally advanced NSCLC, which might ultimately contribute to improved clinical outcomes and reductions in frequency of treatment-related adverse events in this patient group. In this review, we provide a comprehensive overview of available clinical data supporting the use of PET imaging for IGART in patients with locally advanced NSCLC.


KEY WORDS: Carcinoma, non-small-cell lung - Radiotherapy - Positron-emission tomography

top of page