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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 March;62(1):101-11

DOI: 10.23736/S1824-4785.17.02810-2

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Association between semiquantitative PET parameters and molecular subtypes of breast invasive ductal carcinoma

Serena CHIACCHIO 1 , Laura EVANGELISTA 2, Abedallatif ALSHARIF 3, Gianpiero MANCA 1, Fabio DI MARTINO 4, Anna NEGRI 5, Manuel TREDICI 1, Anna R. CERVINO 2, Giulia PUCCINI 1, Elena FILIDEI 6, Matteo GHILLI 7, Antonio G. NACCARATO 8, Manuela RONCELLA 7, Duccio VOLTERRANI 1

1 Regional Center of Nuclear Medicine, Department of Diagnostic Radiology and Vascular Radiology and Interventional and Nuclear Medicine, University Hospital of Pisa, Pisa, Italy; 2 Unit of Radiotherapy and Nuclear Medicine, Istituto Oncologico Veneto (IOV), IRCC, Padua, Italy; 3 University of Jordan, Amman, Jordan; 4 Health Physics Division, University Hospital of Pisa, Pisa, Italy; 5 Unit of Medical Physics, Istituto Oncologico Veneto (IOV), IRCC, Padua, Italy; 6 Unit of Medical Physics, Fondazione “G. Monasterio”, Pisa, Italy; 7 Unit of Senology, University Hospital of Pisa, Pisa, Italy; 8 Section of Pathology, Department of Surgery, University of Pisa, Pisa, Italy


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BACKGROUND: Molecular subtypes of breast cancer have been proposed since 2012. The correlation between various baseline [18F]fluorodeoxyglucose ([18F]FDG) uptake parameters, including total lesion glycolysis (TLG), and molecular subtypes of primary breast cancer lesions in patients with invasive ductal cancer will be investigated.
METHODS: Staging [18F]FDG PET/CT for breast invasive ductal carcinoma were retrospectively evaluated. Breast lesions were examined for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation index (Ki-67). Breast tumors were classified into five molecular subtypes: Luminal A, Luminal B-HER2(-), Luminal B-HER2(+), HER2(+) and Basal or Triple Negative cancers. The correlations between tumor characteristics and PET semiquantitative data of primary breast lesion (SUVmean, SUVmax, Mean tumor volume (MTV), TLG) were assessed. Specific Breast Uptake Ratio (SBUR) is used as a new quantification method of breast uptake to correct for physiological background activity.
RESULTS: Fifty-eight patients were included. TLG was significantly higher in triple negative group when compared with luminal A (P<0.01). Significantly higher uptake was found in triple negative lesions when compared with luminal B-HER2(-) and luminal B-HER2(+) categories using SUVmax, SUVmean and TLG (all P<0.05). Conversely, no statistically significant difference for [18F]FDG uptake was observed between all other molecular subtypes. No value of SBUR in terms of correlation with histopathological parameters was demonstrated.
CONCLUSIONS: TLG was superior to SUVmax and SUVmean in differentiating between triple negative breast cancer lesions and all other molecular subtypes. SBUR was not different statistically between various molecular subtypes.


KEY WORDS: Carcinoma, ductal, breast - Molecular typing - Fluorodeoxyglucose F18

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Publication History

Issue published online: January 25, 2018
Article first published online: September 1, 2015
Manuscript accepted: July 31, 2015
Manuscript revised: June 23, 2015
Manuscript received: March 31, 2015

Cite this article as

Chiacchio S, Evangelista L, Alsharif A, Manca G, Di Martino F, Negri A, et al. Association between semiquantitative PET parameters and molecular subtypes of breast invasive ductal carcinoma. Q J Nucl Med Mol Imaging 2018;62:101-11. DOI: 10.23736/S1824-4785.17.02810-2

Corresponding author e-mail

chiacchioserena@gmail.com