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THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Journal on Nuclear Medicine and Molecular Imaging


A Journal on Nuclear Medicine and Molecular Imaging
Affiliated to the Society of Radiopharmaceutical Sciences and to the International Research Group of Immunoscintigraphy
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The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2018 March;62(1):40-55

DOI: 10.23736/S1824-4785.17.03053-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Hybrid imaging in Crohn’s disease: from SPECT/CT to PET/MR and new image interpretation criteria

Onofrio CATALANO 1, 2, Francesca MACCIONI 3, Chiara LAURI 4, Sveva AULETTA 2, 4 , Rudi DIERCKX 2, Alberto SIGNORE 2, 4

1 Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 2 Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center, Groningen, The Netherlands; 3 Department of Radiological Sciences, Oncology and Pathology, Umberto I Hospital, Sapienza University Rome, Rome, Italy; 4 Unit of Nuclear Medicine, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, Rome, Italy


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Crohn’s disease is a chronic relapsing disease characterized by mucosal inflammation, lymphocytes infiltration and fibrotic strictures. Usually, the assessment of location, extension, inflammatory activity and severity of intestinal lesions is complex and invasive with endoscopic methods or histological and biochemical investigations. Thus, the diagnosis remains a challenge for the management of patients. Nuclear medicine techniques, in particular hybrid and molecular imaging, might offer a valid option for the evaluation and determination of the prognosis of the disease. Indeed, imaging methods provide a non-invasive, reproducible and quantitative analysis. An overview of the currently available multimodality imaging techniques in Crohn’s disease are reviewed, with particular regard to positron-emission tomography/magnetic resonance and the choice of the best evaluation Score, explaining advantages and disadvantages of each one, with particular regard to their potential role for the assessment of disease activity and extent of inflammation in order to improve the diagnosis. We propose new interpretation criteria for PET/MR images.


KEY WORDS: Crohn disease - Tomography, emission-computed, single-photon - Positron-emission tomography - Magnetic resonance imaging - Multimodal Imaging

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Publication History

Issue published online: January 25, 2018
Article first published online: November 30, 2017
Manuscript accepted: November 29, 2017
Manuscript received: November 16, 2017

Cite this article as

Catalano O, Maccioni F, Lauri C, Auletta S, Dierckx R, Signore A. Hybrid imaging in Crohn’s disease: from SPECT/CT to PET/MR and new image interpretation criteria. Q J Nucl Med Mol Imaging 2018;62:40-55. DOI: 10.23736/S1824-4785.17.03053-9

Corresponding author e-mail

sveva.auletta@hotmail.it