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REVIEW  PRECLINICAL IMAGING 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2017 March;61(1):48-59

DOI: 10.23736/S1824-4785.16.02960-5

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Cardiovascular preclinical imaging

Stephan G. NEKOLLA 1, Christoph RISCHPLER 1, Anna PASCHALI 2, Constantinos ANAGNOSTOPOULOS 2

1 Clinic of Nuclear Medicine, Technical University, Munich, Germany; 2 Biomedical Research Foundation Academy of Athens, Athens, Greece


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Non-invasive imaging in the form of single-photon emission-computed tomography (SPECT), positron-emission tomography (PET), computed tomography (CT), echocardiography or magnetic resonance imaging (MRI) is a very useful tool for cardiovascular research as it allows assessment of biological processes in vivo. Nuclear imaging with SPECT and PET offers the advantage of high sensitivity, the potential for serial imaging, and reliable quantification. Currently a wide range of established as well as innovative agents is available and can be imaged with dedicated preclinical and clinical SPECT and PET imaging systems. These scanners can be equipped with CT and MRI components to form hybrid imaging systems. This review provides an outline on SPECT and PET as capable tools for translational research in cardiology as part of a workflow similar to the one used in clinical imaging illustrating the concept “from bench to bedside”.


KEY WORDS: Single-photon emission-computed tomography - Positron-emission tomography - Molecular imaging - Translational medical research

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