ORIGINAL ARTICLES   

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2013 December;57(4):401-11

Copyright © 2013 EDIZIONI MINERVA MEDICA

language: English

Radioguided occult lesion localization of cervical recurrences from differentiated thyroid cancer: technical feasibility and clinical results

Borsò E. ¹, Grosso M. ¹, Boni G. ¹, Manca G. ¹, Bianchi P. ², Puccini M. ³, Arganini M. ⁴, Cabria M. ², Piccardo A. ², Arlandini A. ⁵, Orlandini C. ⁶, Mariani G. ¹ ✉

¹ Regional Center of Nuclear Medicine University of Pisa, Pisa, Italy; ² Nuclear Medicine Division “Galliera” Hospital, Genoa, Italy; ³ Department of Surgery, University of Pisa, Pisa, Italy; ⁴ Division of Surgery, “Versilia” Hospital Lido di Camaiore, Venice, Italy; ⁵ Division of Surgery, “Galliera” Hospital, Genoa, Italy; ⁶ Division of Medical Oncology University Hospital of Pisa, Pisa, Italy

Aim: We explored the feasibility of radioguided occult lesion localization (ROLL) for radioiodine-negative cervical recurrences from differentiated thyroid cancer (DTC).
Methods: The procedure was performed in 32 patients (3 patients being operated twice); 15/32 patients had had multiple prior lymph node dissections (“hostile” anatomy). 99mTc-albumin macro-aggregates (99mTc-MAA) were injected intra-lesionally under ultrasound guidance; 2 to 18 hours later, a hand-held gamma-probe helped to localize the lesions intraoperatively and to ascertain removal of the radiolabeled lesions. Mini-invasive excision of the radiolabelled lesions was performed in 12 cases (m-ROLL), while a modified radical neck dissection was performed in 23 cases after radioguided lymphadenectomy (d-ROLL). Fifty-nine lesions were radiolabelled (mean size 11±4.5 mm).
Results: Radioguidance allowed to identify/remove 56/59 lesions (95%). Some leakage of 99mTc-MAA in the surrounding tissues hampered detection of 3 lesions, which were removed anyway (100% overall localization). Histopathology confirmed metastatic involvement of the radiolabeled lesions and some additional metastases in other nodes. Neither nerve injury nor hypoparathyroidism occurred. After a median follow-up of 29 months, 19 patients were disease-free, 12 patients developed loco-regional recurrences, 1 patient had distant metastases and 1 patient had both loco-regional and distant metastases. Recurrences rates were 33% for m-ROLL and 40% for d-ROLL.
Conclusions: The ROLL technique is feasible in selected patients with loco-regional recurrence from DTC, proving to be particularly useful also in patients already submitted to cervical dissections and/or with small lesions located in surgically difficult sites. It can therefore have a clinical role in the management of cervical DTC recurrences.