FOREWORD  NON-STANDARD PET NUCLIDES 

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2008 June;52(2):166-73

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English

Bifunctional chelates for metal nuclides

Brechbiel M. W.

Radioimmune and Inorganic Chemistry Section Radiation Oncology Branch National Cancer Institute, Bethesda, MD, USA

The use of “non-standard” metallic radionuclides continues to be an expanding field of investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles are all areas of active investigation for both diagnostic and therapeutic applications. All require a common variableæthe need for appropriate chelation chemistry for adequate sequestration of the metallic radionuclide that is equal to the intended application. A brief overview of the array of the chelation chemistry options available to researchers and the means for their selection is provided.