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Original Article   

Journal of Neurosurgical Sciences 2022 Nov 07

DOI: 10.23736/S0390-5616.22.05865-9

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Association of baseline frailty and age with postoperative outcomes in metastatic brain tumor patients

Christine J. COLASACCO 1, Joanna ABOUEZZI 1, Sophia ARBUISO 1, Derek B. ASSERSON 2, Syed F. KAZIM 2, Kyril L. COLE 3, Alis J. DICPINIGAITIS 1, Jose DOMINGUEZ 4, Rohini G. MCKEE 5, Meic H. SCHMIDT 2, William T. COULDWELL 6, Christian A. BOWERS 2

1 School of Medicine, New York Medical College, Valhalla, NY, USA; 2 Department of Neurosurgery, University of New Mexico Hospital, Albuquerque, NM, USA; 3 School of Medicine, University of Utah, Salt Lake City, UT, USA; 4 Department of Neurosurgery, Westchester Medical Center & New York Medical College, Valhalla, NY, USA; 5 Department of Surgery, University of New Mexico, Albuquerque, NM, USA; 6 Department of Neurosurgery, Clinical Neuroscience Center, University of Utah, Salt Lake City, UT, USA


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BACKGROUND: The impact of baseline frailty status versus that of chronological age on surgical outcomes of metastatic brain tumor patients remains largely unknown. The present study aimed to evaluate this relationship for preoperative risk stratification using a large national database.
METHODS: The National Surgical Quality Improvement Program database was queried to extract data of metastatic brain tumor patients who underwent surgery between 2015 and 2019 (n=5,943). Univariate and multivariate analyses were performed to assess the effect of age and modified frailty index-5 (mFI-5) on mortality, major complications, unplanned readmission and reoperation, extended length of stay (eLOS), and non-home discharge.
RESULTS: Both univariate and multivariate analyses demonstrated that frailty status was significantly predictive of 30-day mortality, major complications, eLOS, and non-home discharge. Although increasing age was also a significant predictor of eLOS and discharge to non-home destination, effect sizes were smaller compared with frailty.
CONCLUSIONS: The present study, based on analysis of data from a large national registry, shows that frailty, when compared with age, is a superior predictor of postoperative outcomes in metastatic brain tumor patients. A future prospective study, namely a randomized controlled trial, would be beneficial in helping to corroborate the findings of this retrospective study.


KEY WORDS: Cranial metastases; Frailty; Age; Modified frailty index-5 (mFI-5); Surgical outcomes; National Surgical Quality Improvement Program (NSQIP)

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