Review Article   

Journal of Neurosurgical Sciences 2022 Mar 17

DOI: 10.23736/S0390-5616.22.05600-4

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Acellular nerve grafts with BMSCs/SCs for sciatic nerve regeneration in rats: a meta-analysis

Jie LIANG ¹, Liang LUO ¹, Feifan XIANG ¹, Shuangli LAN ², Xiaoqi TAN ³, Hao GU ¹, Kaiwen YANG ¹, Junwu YE ¹, Lian TANG ¹, YunKang YANG ¹ ✉

¹ Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Sichuan Luzhou,China; ² Department of Hepatobiliary Surgery, Affiliated Hospital of Southwest Medical University, Sichuan Luzhou, China; ³ Dermatology Department, Affiliated Hospital of Southwest Medical University, Sichuan Luzhou, China

INTRODUCTION: to evaluate the effects of acellular nerve grafts (ANGs) with bone marrow mesenchymal stem cells (BMSCs) or Schwann cells (SCs) on the treatment of sciatic nerve defect in rats.
EVIDENCEACQUISITION: Electronic databases were accessed to identify eligible targets. ANGs data were extracted for meta-analysis using Review Manager 5.3.
EVIDENCE SYNTHESIS: The rats subjected to ANGs+BMSCs or ANGs+SCs are characterized by different sciatic nerve function index, nerve conduction, latency, amplitude, myelin sheath thickness, myelinated nerve fibers and gastrocnemius wet weight. Accompanied with evidently superior recovery of limb function. These differences are of statistical significance (P < 0.05) when compared to that of control group with ANGs only.
CONCLUSIONS: ANGs with BMSCs or SCs can promote nerve regeneration and functional recovery in peripheral nerve defects.

KEY WORDS: Peripheral nerve; Bone marrow mesenchymal stem cells; Schwann cells; Acellular nerve grafts; Meta-analysis