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Journal of Neurosurgical Sciences 2021 Jun 10

DOI: 10.23736/S0390-5616.21.05342-X

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

The extent of resection of T2-flair hyperintense area for eloquent glioblastomas: outcomes analysis between awake and general anesthesia patients

Christian CURZI 1, Enrico GIORDAN 2 , Angela GUERRIERO 3, Matteo BENDINI 4, Giuseppe CANOVA 2, Alberto FELETTI 5, Elisabetta MARTON 1, 2

1 Department of Neuroscience, University of Padova, Padova, Italy; 2 Department of Neurosurgery, Aulss2 Marca Trevigiana, Treviso, Italy; 3 Department of Pathology, Aulss2 Marca Trevigiana, Treviso, Italy; 4 Department of Radiology, Aulss2 Marca Trevigiana, Treviso, Italy; 5 Institute of Neurosurgery, Department of Neuroscience, Biomedicine and Movement sciences, University of Verona, Verona, Italy


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BACKGROUND: Maximum safe resection for eloquent areas glioblastomas is the greatest tumor resection achievable without causing neurological deficits. This study aims to assess, through quantitative volumetric analysis, the outcomes of patients with eloquent areas glioblastomas and correlate the extent of resection (EOR), based on MRI T1-contrast enhanced (CE) and T2- fluid-attenuated inversion recovery (FLAIR) sequences, with patient outcomes and overall survival.
METHODS: We prospectively collected and analyzed patients with a diagnosis of primary GBM located in an eloquent area operated between January 2012 and April 2018. We examined 295 consecutive patients' records with GBM and identified 82
eloquent GBMs who met inclusion criteria. We stratified our patients by type of treatment - awake surgery (AS) and general anesthesia (GA) craniotomies. The kind of treatment was correlated with EOR, focusing on exeresis over the limit of the contrast-enhanced signal intensity, including both T1-CE and T2-FLAIR MRI signal alterations.
RESULTS: The overall mean EOR value was higher in AS than in GA on T1-CE (p-value: 0.010) and T2-Flair MRI images (p-value: 0.007). Also, patients who had at least 30% of T2-FLAIR signal resection (EOR ≥ 30%) had a significantly lower risk of death and recurrence (p-value: 0.020), independent of residual T1-CE tumor volume.
CONCLUSIONS: Extensive T2-Flair resection and AS improve overall survival and reduce risk of recurrence while simultaneously minimizing surgical and medical complications among patients with GBMs in eloquent areas.


KEY WORDS: Glioblastoma; Survival; Recurrence; Residual tumor; Extent of resection; Brain tumor; Supratotal

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